Set Degree ≥ 5 and Hub ≥ 0.010. These genes broadcast their expression to many connected tissues—prime candidates for therapeutic targets with broad systemic effects.

Set Betweenness ≥ 0.0005 and Degree ≥ 2. Genes that connect different pathway modules—disrupting these fragments the pathological network.

Set Authority ≥ 0.0005 and Degree ≥ 3. Genes receiving strong signals from many important hubs—key downstream effects in severe COVID-19.

Set Degree ≥ 3 and Closeness Centrality ≥ 0.30. Multi-tissue genes ideal for drugs that modulate systemic COVID-19 mechanisms.

Set Degree = 1-2 and Eccentricity = 4. Find genes with localized roles—potential tissue-specific interventions.

Set Betweenness ≥ 0.0012, Hub ≥ 0.020, and Degree ≥ 3. Genes that are hubs, bridges, and potentially offering maximum therapeutic leverage.